Aims and Scope

The Open Immunology Journal is an open access online journal, which publishes research articles, reviews/mini-reviews, letters and guest edited thematic issues on Immunology including (but not limited to) clinical & translational immunology, cellular and molecular immunology, mucosal immunology, reproductive immunology and neuro-immunology. The journal also covers the pathogenesis, pathophysiology, treatment of autoimmune diseases, diagnostic auto-antibody tests and areas of clinical interest of autoimmunity.

The Open Immunology Journal, a peer-reviewed journal, is an important and reliable source of current information on developments in the field. The emphasis will be on publishing quality papers rapidly and freely available to the researchers worldwide.

Editor's Choice

Histamine, Histamine Receptors, and their Role in Immunomodulation: An Updated Systematic Review

Mohammad Shahid, Trivendra Tripathi, Farrukh Sobia, Shagufta Moin, Mashiatullah Siddiqui, Rahat Ali Khan

Histamine, a biological amine, is considered as a principle mediator of many pathological processes regulating several essential events in allergies and autoimmune diseases. It stimulates different biological activities through differential expression of four types of histamine receptors (H1R, H2R, H3R and H4R) on secretion by effector cells (mast cells and basophils) through various immunological or non-immunological stimuli. Since H4R has been discovered very recently and there is paucity of comprehensive literature covering new histamine receptors, their antagonists/agonists, and role in immune regulation and immunomodulation, we tried to update the current aspects and fill the gap in existing literature. This review will highlight the biological and pharmacological characterization of histamine, histamine receptors, their antagonists/agonists, and implications in immune regulation and immunomodulation.

March 4, 2009

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