Editorial - Introductory Overview: γδ T-Cells at the Cross-Road of Innate and Adaptive Immunity
Dieter KabelitzInstitute of Immunology UK S-H Campus Kiel Arnold-Heller-Str. 3Haus 17 D-24105 KielGermanyE-mail: Email: email@example.com
Identifiers and Pagination:Year: 2009
First Page: 103
Last Page: 105
Publisher Id: TOIJ-2-103
Article History:Electronic publication date: 23/10/2009
Collection year: 2009
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
γδ T-lymphocytes are a numerically small subset of T-lymphocytes which differ from conventional αβ T-lymphocytes primarily in respect to the ligands recognized by the T-cell antigen receptor. In this regard, human γδ T-cells differ significantly from their murine counterpart, because only human but not mouse γδ T-cells recognize small phosphorylated metabolites that are produced by many bacteria and parasites, but also by transformed eukaryotic cells. γδ T-cells contribute to local immune surveillance and are involved in immune defense against infection and tumor formation. Based on their potent anti-tumor activity, immunotherapeutic protocols aimed at the activation of tumor-reactive γδ T-cells have entered clinical studies..