Human γδ T Cells and Immune Regulation
Zheng W. Chen*
Identifiers and Pagination:Year: 2009
First Page: 127
Last Page: 134
Publisher Id: TOIJ-2-127
Article History:Received Date: 22/5/2009
Revision Received Date: 23/5/2009
Acceptance Date: 22/7/2009
Electronic publication date: 23/10/2009
Collection year: 2009
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Human γδ T cells appear to belong to non-classical T cells with both innate and adaptive immune features. Vγ2Vδ2 (also termed Vγ9Vδ2) T cell subset exists only in primates, and in humans that represents a major γδ T cell subpopulation in the blood. Vγ2Vδ2 T cells remain to be the only γδ T cell subpopulation that can recognize a welldefined foreign microbial phosphoantigen. This article reviews the recent progress in our understanding immune regulation of Vγ2Vδ2 T cells.